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Journal Articles

Application of PZC to $$^{188}$$W/$$^{188}$$Re generators

Matsuoka, Hiromitsu; Hashimoto, Kazuyuki; Hishinuma, Yukio*; Ishikawa, Koji*; Terunuma, Hitoshi*; Tatenuma, Katsuyoshi*; Uchida, Shoji*

Journal of Nuclear and Radiochemical Sciences, 6(3), p.189 - 191, 2005/12

https://doi.org/10.14494/jnrs2000.6.3_189

Applicability of Mo adsorbent PZC(Poly Zirconium Compound) for $$^{188}$$W/$$^{188}$$Re generator was investigated. Long term stability of adsorption of $$^{188}$$W to the PZC column, elution of $$^{188}$$Re from PZC column, desorption of $$^{188W}$$ from PZC column, and labeling of Hydroxyethylidene Diphosphonic Acid(HEDP) and Mercaptoacetyltriglycine(MAG3) with $$^{188}$$Re eluted from PZC column were tested. The PZC generator gave reproducible $$^{188}$$Re elution yields with low $$^{188}$$W parent breakthrough for a long period of time(about 5 months), that is the $$^{188}$$W/$$^{188}$$Re generator using PZC has a potential for practical use.

Journal Articles

Labeling of bifunctional chelating agent, MAG3, with carrier-free $$^{188}$$Re

Hashimoto, Kazuyuki; Wan, K. W. H. B. B.*; Matsuoka, Hiromitsu

Journal of Nuclear and Radiochemical Sciences, 6(3), p.193 - 196, 2005/12

https://doi.org/10.14494/jnrs2000.6.3_193

The radioisotopes of rhenium ($$^{186}$$Re and $$^{188}$$Re) are attractive radionuclides for radiotherapy because of their energetic beta particles and gamma rays suitable for imaging. Mercaptoacetyltriglycine, MAG3 (N$$_{3}$$S ligand), is a useful bifunctional ligand in labeling monoclonal antibodies with metallic radionuclides. In this study, the labeling of MAG3 with carrier-free $$^{188}$$Re from a $$^{188}$$W/$$^{188}$$Re generator was investigated in detail. The $$^{188}$$Re-MAG3 complex was synthesized by the direct labeling method and by the indirect labeling method using a transfer ligand (citric acid or gluconic acid). The dependence of the labeling yield upon the reaction conditions such as the concentrations of tin(II) chloride dihydrate as a reducing agent, S-benzoyl MAG3 and the transfer ligand, pH, temperature, reaction time and the addition of a carrier was examined. The labeling yield of $$^{188}$$Re-MAG3 synthesized by the all method was over 90% under the optimum conditions.

Journal Articles

Development of a Rhenium-186-labeled MAG3-conjugated bisphosphonate for the palliation of metastatic bone pain based on the concept of bifunctional radiopharmaceuticals

Ogawa, Kazuma*; Mukai, Takahiro*; Arano, Yasushi*; Ono, Masahiro*; Hanaoka, Hirofumi*; Ishino, Seigo*; Hashimoto, Kazuyuki; Nishimura, Hiroshi*; Saji, Hideo*

Bioconjugate Chemistry, 16(4), p.751 - 757, 2005/07

https://doi.org/10.1021/bc040249w
 Times Cited Count：61 Percentile：86.86(Biochemical Research Methods)

Rhenium-186-1-hydroxyethylidene-1,1-diphosphonate ($$^{186}$$Re-HEDP) has been used for the palliation of metastatic bone pain. Delayed blood clearance and high gastric uptake of radioactivity have been observed upon injection, due to the instability of $$^{186}$$Re-HEDP in vivo. In this study, on the basis of the concept of bifunctional radiopharmaceuticals, we designed a stable $$^{186}$$Re-mercaptoacetylglycylglycylglycine (MAG3) complex-conjugated bisphosphonate ($$^{186}$$Re-MAG3-HBP). After purification by HPLC, $$^{186}$$Re-MAG3-HBP was synthesized with a radiochemical purity of over 95%. In biodistribution experiments, the radioactivity level of$$^{186}$$Re-MAG3-HBP in bone was significantly higher than that of $$^{186}$$Re-HEDP. Blood clearance of $$^{186}$$Re-MAG3-HBP was faster than that of $$^{186}$$Re-HEDP. In addition, the gastric accumulation of $$^{186}$$Re-MAG3-HBP radioactivity was lower than that of $$^{186}$$Re-HEDP. In conclusion, $$^{186}$$Re-MAG3-HBP is expected to be a useful radiopharmaceutical for the palliation of metastatic bone pain.

Journal Articles

Design of a radiopharmaceutical for the palliation of painful bone metastases; Rhenium-186-labeled bisphosphonate derivative

Ogawa, Kazuma*; Mukai, Takahiro*; Arano, Yasushi*; Hanaoka, Hirofumi*; Hashimoto, Kazuyuki; Nishimura, Hiroshi*; Saji, Hideo*

Journal of Labelled Compounds and Radiopharmaceuticals, 47(11), p.753 - 761, 2004/11

https://doi.org/10.1002/jlcr.864
 Times Cited Count：28 Percentile：61.65(Biochemical Research Methods)

no abstracts in English

Journal Articles

Analysis of $$^{188}$$Re-EDTMP complexes by HPLC and ultrafiltration

Hashimoto, Kazuyuki; Matsuoka, Hiromitsu

Radiochimica Acta, 92(4-6), p.285 - 290, 2004/07

https://doi.org/10.1524/ract.92.4.285.35587
 Times Cited Count：1 Percentile：10.03(Chemistry, Inorganic & Nuclear)

no abstracts in English

Journal Articles

Separation, purification of $$^{177}$$Lu$$^{m}$$ and preparation of $$^{177}$$Lu$$^{m}$$-EDTMP

Chen, D.*; Hashimoto, Kazuyuki

Journal of Nuclear and Radiochemistry, 26(2), p.84 - 87, 2004/05

no abstracts in English

JAEA Reports

Development of pharmaceuticals with radioactive rhenium for cancer therapy, the second report; Production of $$^{186}$$Re and $$^{188}$$Re, synthesis of labeled compounds and their biodistributions

Consultative Committee of Research on Radioisotopes

JAERI-Research 2004-001, 117 Pages, 2004/02

JAERI-Research-2004-001.pdf:5.26MB

no abstracts in English

Journal Articles

In vivo recognition of Cyclopentadienyltricarbonylrhenium (CpTR) derivatives

Uehara, Tomoya*; Koike, Miho*; Nakata, Hideo*; Miyamoto, Shigehiko*; Motoishi, Shoji; Hashimoto, Kazuyuki; Oku, Naoto*; Nakayama, Morio*; Arano, Yasushi*

Nuclear Medicine and Biology, 30(3), p.327 - 334, 2003/04

https://doi.org/10.1016/S0969-8051(02)00437-7
 Times Cited Count：20 Percentile：50.16(Radiology, Nuclear Medicine & Medical Imaging)

no abstracts in English

Journal Articles

Positron imaging for plant study using positron emitting tracer imaging system (PETIS) and Imaging plate (IP)

Matsuhashi, Shimpei; Uchida, Hiroshi*; Kume, Tamikazu

Radioisotopes, 49(11), p.38 - 50, 2000/11

no abstracts in English

Journal Articles

Development of positron imaging method for plant study

Matsuhashi, Shimpei; Kume, Tamikazu

Hoshasen Kagaku, (70), p.20 - 25, 2000/09

https://ci.nii.ac.jp/naid/10010163184

no abstracts in English

Journal Articles

Labeling with radioactive rhenium for the purpose of the pain relief of cancerous bone metastasis

Ogawa, Kazuma*; Ono, Masahiro*; Fujioka, Yasushi*; Saji, Hideo*; Mukai, Takahiro*; Konishi, Junji*; Uehara, Tomoya*; Arano, Yasushi*; Onoma, Katsuyuki

Kaku Igaku, 37(5), P. 577, 2000/09

no abstracts in English

Journal Articles

Labelling of phosphate compounds with $$beta$$-emitting radionuclides; For bone pain palliation

Hashimoto, Kazuyuki

Radioisotopes, 48(7), p.505 - 506, 1999/07

https://doi.org/10.3769/radioisotopes.48.505

no abstracts in English

Journal Articles

Labelling of aminomethylenephosphonate derivatives with generator-produced $$^{188}$$Re, and a study of their stability

Hashimoto, Kazuyuki

Applied Radiation and Isotopes, 51(3), p.307 - 313, 1999/00

https://doi.org/10.1016/S0969-8043(99)00047-0
 Times Cited Count：12 Percentile：66.1(Chemistry, Inorganic & Nuclear)

no abstracts in English

Journal Articles

Production of positron emitters and application of their labeled compounds to plant studies

Ishioka, Noriko; Matsuoka, Hiromitsu; Watanabe, Satoshi; Osa, Akihiko; Koizumi, Mitsuo; Matsuhashi, Shimpei; Kume, Tamikazu; Sekine, Toshiaki; Uchida, Hiroshi*; Tsuji, Atsunori*; et al.

Journal of Radioanalytical and Nuclear Chemistry, 239(2), p.417 - 421, 1999/00

https://doi.org/10.1007/BF02349523
 Times Cited Count：27 Percentile：86.12(Chemistry, Analytical)

no abstracts in English

Journal Articles

Synthesis of $$^{186}$$Re-DMSA and its biodistributions in mice

*; *; *; *; *; Hashimoto, Kazuyuki; *

Journal of Radioanalytical and Nuclear Chemistry, 239(2), p.385 - 389, 1999/00

https://doi.org/10.1007/BF02349517
 Times Cited Count：2 Percentile：21.17(Chemistry, Analytical)

no abstracts in English

JAEA Reports

Development of pharmaceuticals with radioactive rhenium for cancer therapy; Production of $$^{186}$$Re and $$^{188}$$Re, synthesis of labeled compounds and their biodistributions

JAERI-Research 98-015, 197 Pages, 1998/03

JAERI-Research-98-015.pdf:7.65MB

no abstracts in English

Journal Articles

Production of positron emitter-labeled compounds for plant study using an AVF cyclotron

Ishioka, Noriko

Hoshasen To Sangyo, (80), p.11 - 15, 1998/00

http://ci.nii.ac.jp/naid/40004433047

no abstracts in English

Journal Articles

A New water target system for the production of $$^{18}$$F and $$^{13}$$N to be used in plant study

Ishioka, Noriko; Matsuoka, Hiromitsu; Watanabe, Satoshi; Osa, Akihiko; Koizumi, Mitsuo; Sekine, Toshiaki

Synthesis and Applications of Isotopically Labelled Compounds 1997, p.669 - 672, 1998/00

no abstracts in English

Journal Articles

Preparation of rhenium complexes labeled with carrier-free $$^{188}$$Re for nuclear medicine

Hashimoto, Kazuyuki; S.Bagiawati*; S.Islam*

Radiochemistry, 39(5), p.389 - 393, 1997/00

no abstracts in English

JAEA Reports

None

PNC TJ1621 96-001, 80 Pages, 1996/03

PNC-TJ1621-96-001.pdf:2.34MB

no abstracts in English

32 (Records 1-20 displayed on this page)